Publications

2026

  • Wang Y, Edin ML, Jing N, Lih GB, Yang J, Yeliseyev V, Zeldin DC, and Zhang G. (2026) Gut Microbiota Modulate Adipose Eicosanoid Metabolism: Potential Roles of the Lipoxygenase Pathway. FASEB J, https://doi.org/10.1096/fj.202504725R.
  • Lei L, Jing N, Xie M, Zhang J, Hammock BD, Yang J, and Zhang G. (2026) Liquid Chromatography–Tandem Mass Spectrometry-Based Targeted Lipidomic Analysis of Obesity-Related Colorectal Cancer: Potential Roles of the CYP Eicosanoid Pathway. J Nutr, doi: 10.1016/j.tjnut.2025.101311.
  • Jing N, Edin ML, Lih FB, Wang Y, Matsukuma KE, Graves JP, Liu F, Fang J, Zeldin DC, and Zhang G. (2026) CYP2C29 monooxygenase promotes CDAA-HFD-induced liver fibrosis. Free Radic Biol Med, 243: 338-350. doi: 10.1016/j.freeradbiomed.2025.11.028.
  • Ead AS, Wirkus J, Machuca J, Wang Y, Vahmani P, Matsukuma KE, Zhang G, Mackenzie GG. (2026) Timing-dependent effects of omega-3 fatty acids on adipose tissue and tumorigenesis in obesity-driven pancreatic cancer in mice. J Nutr, doi: 10.1016/j.tjnut.2025.101286.

2025

  • Watkins BA, Watkins JR, Shin AC, Zhang G, Cremonini E, Niraula SR, Rucker RB. (2025) Application of AI-assisted methodology to evaluate diet and ingredient formulations for rodent models in nutrition and health research. J Nutr Biochem, 146:110046. https://doi.org/10.1016/j.jnutbio.2025.110046.
  • Jing N, Edin ML, Wang Y, Yang J, Lih FB, Yeliseyev V, Liu F, Ding Y, Zeldin DC, Zhang G, (2025) The gut microbiota mediates epoxy eicosanoid metabolism in the colon. J Biol Chem, 301:110338. https://doi.org/10.1016/j.jbc.2025.110338.
  • Wirkus J, Ead AS, Krga I, Wang Y, Pontifex MG, Muller M, Vauzour D, Matsukuma KE, Zhang G, Mackenzie GG. (2025) Normalizing body weight with a dietary strategy mitigates obesity-accelerated pancreatic carcinogenesis in mice. J Nutr, doi: 10.1016/j.tjnut.2025.05.039.
  • Wang W, Wang Y, Sanidad KZ, Wang Y, Zhang J, Yang W, Sun Q, Bayram I, Song R, Yang H, Johnson D, Sherman HL, Kim D, Minter LM, Wong JJ, Zeng MY, Decker EA, Zhang G. (2025) Oxidized polyunsaturated fatty acid promotes colitis and colitis-associated tumorigenesis in mice. J Crohns Colitis, jjae148. doi: 10.1093/ecco-jcc/jjae148. 

2024

  • Hateley C, Olona A, Halliday L, Edin ML, Ko JH, Forlano R, Terra X, Lih FB, Beltran-Debon R, Manousou P, Purkayastha S, Moorthy K, Thursz MR, Zhang G, Goldin RD, Zeldin DC, Petretto E, Behmoaras J. (2024) Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity. EBioMedicine, 103:105127. doi: 10.1016/j.ebiom.2024.105127.

2023

  • Zhang, J., Yang, J., Duval, C., Edin, M.L., Williams, A., Lei, L., Tu, M., Pourmand, E., Song, R., Graves, J.P., DeGraff, L.M., Wong, J.J., Wang, Y., Sun, Q., Sanidad, K.Z., Wong, S., Han, Y., Zhang, Z., Lee, K.S.S., Park, Y., Xiao, H., Liu, Z., Decker, E.A., Cui, W., Zeldin, D.C. & Zhang, G. (2023). CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid. FASEB J, 37(7), e23009. https://doi.org/10.1096/fj.202300786R.
  • Zhang, H., Sanidad, K.Z., Zhang, J., Wang, G., Zhang, R., Hu, C., Lin, Y., Haggerty, T.D., Parsonnet, J., Zheng, Y., Zhang, G. & Cai, Z. (2023). Microbiota-mediated reactivation of triclosan oxidative metabolites in colon tissues. J Hazard Mater, 445, 130509. https://doi.org/10.1016/j.jhazmat.2022.130509.
  • Wang, W., Wang, Y., Yang, J., Wagner, K.M., Hwang, S.H., Cheng, J., Singh, N., Edwards, P., Morisseau, C., Zhang, G., Panigrahy, D. & Hammock, B.D. (2023). Aflatoxin B(1) exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner. Ecotoxicol Environ Saf, 249, 114417. https://doi.org/10.1016/j.ecoenv.2022.114417.
  • Mohan, D., Sherman, H.L., Mitra, A., Lawlor, R., Shanthalingam, S., Ullom, J., Pobezinskaya, E.L., Zhang, G., Osborne, B.A., Pobezinsky, L.A., Tew, G.N. & Minter, L.M. (2023). LKB1 isoform expression modulates T cell plasticity downstream of PKCθ and IL-6. Mol Immunol, 157, 129-141. https://doi.org/10.1016/j.molimm.2023.03.020. 

2022

  • Zhang, J., Walker, M.E., Sanidad, K.Z., Zhang, H., Liang, Y., Zhao, E., Chacon-Vargas, K., Yeliseyev, V., Parsonnet, J., Haggerty, T.D., Wang, G., Simpson, J.B., Jariwala, P.B., Beaty, V.V., Yang, J., Yang, H., Panigrahy, A., Minter, L.M., Kim, D., Gibbons, J.G., Liu, L., Li, Z., Xiao, H., Borlandelli, V., Overkleeft, H.S., Cloer, E.W., Major, M.B., Goldfarb, D., Cai, Z., Redinbo, M.R. & Zhang, G. (2022). Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun, 13(1), 136. https://doi.org/10.1038/s41467-021-27762-y. 
  • Tu, M., Sun, Q., Zhang, J. & Zhang, G. (2022). Comparative Effects of Traditional Versus Genetically Modified Soybean Oils on Colon Tumorigenesis in Mice. Foods, 11(13). https://doi.org/10.3390/foods11131937.
  • Sanidad, K.Z., Wang, G., Panigrahy, A. & Zhang, G. (2022). Triclosan and triclocarban as potential risk factors of colitis and colon cancer: Roles of gut microbiota involved. Sci Total Environ, 842, 156776. https://doi.org/10.1016/j.scitotenv.2022.156776. 

2021

  • Zhang, H., Sanidad, K.Z., Zhu, L., Parsonnet, J., Haggerty, T.D., Zhang, G. & Cai, Z. (2021). Frequent occurrence of triclosan hydroxylation in mammals: A combined theoretical and experimental investigation. J Hazard Mater, 407, 124803. https://doi.org/10.1016/j.jhazmat.2020.124803.
  • Zhang, H., Liang, Y., Wu, P., Shi, X., Zhang, G. & Cai, Z. (2021). Continuous Dermal Exposure to Triclocarban Perturbs the Homeostasis of Liver-Gut Axis in Mice: Insights from Metabolic Interactions and Microbiome Shifts. Environ Sci Technol, 55(8), 5117-5127. https://doi.org/10.1021/acs.est.0c08273.
  • Wang, G., Zhang, H., Zhang, J., Sanidad, K.Z., Yeliseyev, V., Parsonnet, J., Haggerty, T.D., Yang, H., Ai, L., Xie, M., Cai, Z. & Zhang, G. (2021). Metabolic fate of environmental chemical triclocarban in colon tissues: roles of gut microbiota involved. Sci Total Environ, 787, 147677. https://doi.org/10.1016/j.scitotenv.2021.147677.
  • Morrison, I.J., Zhang, J., Lin, J., Murray, J.E., Porter, R., Langat, M.K., Sadgrove, N.J., Barker, J., Zhang, G. & Delgoda, R. (2021). Potential chemopreventive, anticancer and anti-inflammatory properties of a refined artocarpin-rich wood extract of Artocarpus heterophyllus Lam. Sci Rep, 11(1), 6854. https://doi.org/10.1038/s41598-021-86040-5.
  • Lei, L., Zhang, J., Decker, E.A. & Zhang, G. (2021). Roles of Lipid Peroxidation-Derived Electrophiles in Pathogenesis of Colonic Inflammation and Colon Cancer. Front Cell Dev Biol, 9, 665591. https://doi.org/10.3389/fcell.2021.665591.
  • Lei, L., Yang, J., Zhang, J. & Zhang, G. (2021). The lipid peroxidation product EKODE exacerbates colonic inflammation and colon tumorigenesis. Redox Biol, 42, 101880. https://doi.org/10.1016/j.redox.2021.101880. 

2020

  • Zhou, J., Wang, W., Zhang, J., Du, Z., Yang, H. & Zhang, G. (2020). Click chemistry-based imaging to study the tissue distribution of the curcumin-protein complex in mice. Food Funct, 11(2), 1684-1691. https://doi.org/10.1039/c9fo02012h.
  • Zhao, B., Yang, T., Qu, Y., Mills, A.J., Zhang, G. & He, L. (2020). Rapid capture and SERS detection of triclosan using a silver nanoparticle core - protein satellite substrate. Sci Total Environ, 716, 137097. https://doi.org/10.1016/j.scitotenv.2020.137097.
  • Zhang, J., Tu, M., Liu, Z. & Zhang, G. (2020). Soluble epoxide hydrolase as a therapeutic target for obesity-induced disorders: roles of gut barrier function involved. Prostaglandins Leukot Essent Fatty Acids, 162, 102180. https://doi.org/10.1016/j.plefa.2020.102180.
  • Zhang, J., Freund, M.A., Culler, M.D., Yang, R., Chen, P.B., Park, Y., Decker, E.A. & Zhang, G. (2020). How To Stabilize ω-3 Polyunsaturated Fatty Acids (PUFAs) in an Animal Feeding Study?-Effects of the Temperature, Oxygen Level, and Antioxidant on Oxidative Stability of ω-3 PUFAs in a Mouse Diet. J Agric Food Chem, 68(46), 13146-13153. https://doi.org/10.1021/acs.jafc.9b08298.
  • Yang, H., Sanidad, K.Z., Wang, W., Xie, M., Gu, M., Cao, X., Xiao, H. & Zhang, G. (2020). Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved. Gut Microbes, 12(1), 1690364. https://doi.org/10.1080/19490976.2019.1690364.
  • Xie, M., Zhang, H., Wang, W., Sherman, H.L., Minter, L.M., Cai, Z. & Zhang, G. (2020). Triclocarban Exposure Exaggerates Spontaneous Colonic Inflammation in Il-10-/- Mice. Toxicol Sci, 174(1), 92-99. https://doi.org/10.1093/toxsci/kfz248.
  • Xie, M., Yang, J., Zhang, J., Sherman, H.L., Zhang, Z., Minter, L.M., Hammock, B.D., Park, Y. & Zhang, G.(2020). Effects of Linoleic Acid-Rich Diet on Plasma Profiles of Eicosanoids and Development of Colitis in Il-10(-/-) Mice. J Agric Food Chem, 68(29), 7641-7647. https://doi.org/10.1021/acs.jafc.0c03024.
  • Wang, Y., Yang, J., Wang, W., Sanidad, K.Z., Cinelli, M.A., Wan, D., Hwang, S.H., Kim, D., Lee, K.S.S., Xiao, H., Hammock, B.D. & Zhang, G. (2020). Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. Proc Natl Acad Sci U S A, 117(15), 8431-8436. https://doi.org/10.1073/pnas.1916189117.
  • Wang, Y., Dattmore, D.A., Wang, W., Pohnert, G., Wolfram, S., Zhang, J., Yang, R., Decker, E.A., Lee, K.S.S. & Zhang, G. (2020). trans, trans-2,4-Decadienal, a lipid peroxidation product, induces inflammatory responses via Hsp90- or 14-3-3ζ-dependent mechanisms. J Nutr Biochem, 76, 108286. https://doi.org/10.1016/j.jnutbio.2019.108286.
  • Tu, M., Wang, W., Zhang, G. & Hammock, B.D. (2020). ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved. Nutrients, 12(11). https://doi.org/10.3390/nu12113301.
  • Mahalak, K.K., Firrman, J., Lee, J.J., Bittinger, K., Nuñez, A., Mattei, L.M., Zhang, H., Fett, B., Bobokalonov, J., Arango-Argoty, G., Zhang, L., Zhang, G. & Liu, L.S. (2020). Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro. PLoS One, 15(6), e0234046. https://doi.org/10.1371/journal.pone.0234046.
  • Edin, M.L., Duval, C., Zhang, G. & Zeldin, D.C. (2020). Role of linoleic acid-derived oxylipins in cancer. Cancer Metastasis Rev, 39(3), 581-582. https://doi.org/10.1007/s10555-020-09904-8.
  • Cao, X., Han, Y., Gu, M., Du, H., Song, M., Zhu, X., Ma, G., Pan, C., Wang, W., Zhao, E., Goulette, T., Yuan, B., Zhang, G. & Xiao, H. (2020). Foodborne Titanium Dioxide Nanoparticles Induce Stronger Adverse Effects in Obese Mice than Non-Obese Mice: Gut Microbiota Dysbiosis, Colonic Inflammation, and Proteome Alterations. Small, 16(36), e2001858. https://doi.org/10.1002/smll.202001858. 

2019

  • Zhang, J., Sanidad, K.Z. & Zhang, G. (2019). Cytochrome P450 monooxygenase/soluble epoxide hydrolase-mediated eicosanoid pathway in colorectal cancer and obesity-associated colorectal cancer. Oncoscience, 6(9-10), 371-375. https://doi.org/10.18632/oncoscience.488.
  • Zhang, J., Chen, X., Yang, R., Ma, Q., Qi, W., Sanidad, K.Z., Park, Y., Kim, D., Decker, E.A. & Zhang, G. (2019). Thermally Processed Oil Exaggerates Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice. Cancer Prev Res (Phila), 12(11), 741-750. https://doi.org/10.1158/1940-6207.Capr-19-0226. 
  • Yang, T., Qu, Y., Hickey, M., Wang, W., Zhao, B., Bi, S., Zhang, G. & He, L. (2019). Mapping of Pesticide Transmission on Biological Tissues by Surface Enhanced Raman Microscopy with a Gold Nanoparticle Mirror. ACS Appl Mater Interfaces, 11(47), 44894-44904. https://doi.org/10.1021/acsami.9b16084.
  • Yang, H., Wang, W. & Zhang, G. (2019). Consumer Antimicrobials on Gut Microbiota and Gut Health. DNA Cell Biol, 38(1), 7-9. https://doi.org/10.1089/dna.2018.4483.
  • Yang, H., Sukamtoh, E., Du, Z., Wang, W., Ando, M., Kwakwa, Y.N., Zhang, J. & Zhang, G. (2019). Click chemistry approach to characterize curcumin-protein interactions in vitro and in vivo. J Nutr Biochem, 68, 1-6. https://doi.org/10.1016/j.jnutbio.2019.02.010.
  • Wang, Y., Wang, W., Yang, H., Shao, D., Zhao, X. & Zhang, G. (2019). Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of Toll-like receptor 4 signaling. Free Radic Biol Med, 131, 237-242. https://doi.org/10.1016/j.freeradbiomed.2018.11.037.
  • Wang, W., Yang, J., Edin, M.L., Wang, Y., Luo, Y., Wan, D., Yang, H., Song, C.Q., Xue, W., Sanidad, K.Z., Song, M., Bisbee, H.A., Bradbury, J.A., Nan, G., Zhang, J., Shih, P.B., Lee, K.S.S., Minter, L.M., Kim, D., Xiao, H., Liu, J.Y., Hammock, B.D., Zeldin, D.C. & Zhang, G. (2019). Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis. Cancer Res, 79(8), 1822-1830. https://doi.org/10.1158/0008-5472.Can-18-3221.
  • Wang, W., Sanidad, K.Z. & Zhang, G. (2019). Cytochrome P450 Eicosanoid Signaling Pathway in Colorectal Tumorigenesis. Adv Exp Med Biol, 1161, 115-123. https://doi.org/10.1007/978-3-030-21735-8_11.
  • Sanidad, K.Z., Xiao, H. & Zhang, G. (2019). Triclosan, a common antimicrobial ingredient, on gut microbiota and gut health. Gut Microbes, 10(3), 434-437. https://doi.org/10.1080/19490976.2018.1546521.
  • Sanidad, K.Z., Sukamtoh, E., Xiao, H., McClements, D.J. & Zhang, G. (2019). Curcumin: Recent Advances in the Development of Strategies to Improve Oral Bioavailability. Annu Rev Food Sci Technol, 10, 597-617.https://doi.org/10.1146/annurev-food-032818-121738.
  • Rakariyatham, K., Du, Z., Yuan, B., Gao, Z., Song, M., Pan, C., Han, Y., Wu, X., Tang, Z., Zhang, G. & Xiao, H. (2019). Inhibitory effects of 7,7'-bromo-curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation. Eur J Pharmacol, 858, 172479. https://doi.org/10.1016/j.ejphar.2019.172479.
  • Luo, Y., Wu, M.Y., Deng, B.Q., Huang, J., Hwang, S.H., Li, M.Y., Zhou, C.Y., Zhang, Q.Y., Yu, H.B., Zhao, D.K., Zhang, G., Qin, L., Peng, A., Hammock, B.D. & Liu, J.Y. (2019). Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK. Proc Natl Acad Sci U S A, 116(11), 5154-5159. https://doi.org/10.1073/pnas.1815746116.
  • Hao, T., Xie, Z., Wang, M., Liu, L., Zhang, Y., Wang, W., Zhang, Z., Zhao, X., Li, P., Guo, Z., Gao, S., Lou, C., Zhang, G., Merritt, J., Horsman, G.P. & Chen, Y. (2019). An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters. Nat Commun, 10(1), 3665. https://doi.org/10.1038/s41467-019-11673-0.
  • Han, Y., Song, M., Gu, M., Ren, D., Zhu, X., Cao, X., Li, F., Wang, W., Cai, X., Yuan, B., Goulette, T., Zhang, G.& Xiao, H. (2019). Dietary Intake of Whole Strawberry Inhibited Colonic Inflammation in Dextran-Sulfate-Sodium-Treated Mice via Restoring Immune Homeostasis and Alleviating Gut Microbiota Dysbiosis. J Agric Food Chem, 67(33), 9168-9177. https://doi.org/10.1021/acs.jafc.8b05581. 

2018

  • Yang, H., Wang, W., Romano, K.A., Gu, M., Sanidad, K.Z., Kim, D., Yang, J., Schmidt, B., Panigrahy, D., Pei, R., Martin, D.A., Ozay, E.I., Wang, Y., Song, M., Bolling, B.W., Xiao, H., Minter, L.M., Yang, G.Y., Liu, Z., Rey, F.E. & Zhang, G. (2018). A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice. Sci Transl Med, 10(443). https://doi.org/10.1126/scitranslmed.aan4116. 

    >80 media coverage by UMass-Amherst, Los Angeles Times, Popular Science, Canadian Broadcasting Corporation (CBC), Daily Mail, La Vanguardia (Spain). See complete list of press release: https://sciencetm.altmetric.com/details/43005321/news

    In 2019, Colgate announced that it would discontinue its TCS-containing toothpaste, Colgate Total®, one of the top-selling toothpastes in the U.S. (source: https://www.bloomberg.com/news/articles/2019-01-15/colgate-total-toothpaste-to-relaunch-this-time-sans-triclosan)

  • Wang, Y., Wang, W., Sanidad, K.Z., Shih, P.A., Zhao, X. & Zhang, G. (2018). Eicosanoid signaling in carcinogenesis of colorectal cancer. Cancer Metastasis Rev, 37(2-3), 257-267. https://doi.org/10.1007/s10555-018-9739-8. 

  • Wang, W., Yang, J., Zhang, J., Wang, Y., Hwang, S.H., Qi, W., Wan, D., Kim, D., Sun, J., Sanidad, K.Z., Yang, H., Park, Y., Liu, J.Y., Zhao, X., Zheng, X., Liu, Z., Hammock, B.D. & Zhang, G. (2018). Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proc Natl Acad Sci U S A, 115(20), 5283-5288. https://doi.org/10.1073/pnas.1721711115. 

    Media coverage by UMass-Amherst, UC-Davis, Boston Globe, and NIH/NIEHS

    Comment by Yang G. (2018) Proinflammatory enzyme soluble epoxide hydrolase bridges obesity to colonic inflammation and potential carcinogenesis, PNAS, doi: 10.1073/pnas.1807520115

  • Sanidad, K.Z., Yang, H., Wang, W., Ozay, E.I., Yang, J., Gu, M., Karner, E., Zhang, J., Kim, D., Minter, L.M., Xiao, H. & Zhang, G. (2018). Effects of Consumer Antimicrobials Benzalkonium Chloride, Benzethonium Chloride, and Chloroxylenol on Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice. Toxicol Sci, 163(2), 490-499. https://doi.org/10.1093/toxsci/kfy045. 

    Editor’s Highlights: Antimicrobials induce colon inflammation and tumorigenesis. Toxicological Sciences 2018 163:331-2. Doi: 10.1093/toxsci/kfy108.  

    Featured on journal front cover: https://academic.oup.com/toxsci/issue/163/2

  • Kharat, M., Zhang, G. & McClements, D.J. (2018). Stability of curcumin in oil-in-water emulsions: Impact of emulsifier type and concentration on chemical degradation. Food Res Int, 111, 178-186. https://doi.org/10.1016/j.foodres.2018.05.021.
  • Gorin, S., Wakeford, C., Zhang, G., Sukamtoh, E., Matteliano, C.J. & Finch, A.E. (2018). Beneficial effects of an investigational wristband containing Synsepalum dulcificum (miracle fruit) seed oil on the performance of hand and finger motor skills in healthy subjects: A randomized controlled preliminary study. Phytother Res, 32(2), 321-332. https://doi.org/10.1002/ptr.5980. 

2017

  • Zhu, J., Sanidad, K.Z., Sukamtoh, E. & Zhang, G. (2017). Potential roles of chemical degradation in the biological activities of curcumin. Food Funct, 8(3), 907-914. https://doi.org/10.1039/c6fo01770c.
  • Yang, H., Du, Z., Wang, W., Song, M., Sanidad, K., Sukamtoh, E., Zheng, J., Tian, L., Xiao, H., Liu, Z. & Zhang, G. (2017). Structure-Activity Relationship of Curcumin: Role of the Methoxy Group in Anti-inflammatory and Anticolitis Effects of Curcumin. J Agric Food Chem, 65(22), 4509-4515. https://doi.org/10.1021/acs.jafc.7b01792.
  • Wang, W., Yang, J., Qi, W., Yang, H., Wang, C., Tan, B., Hammock, B.D., Park, Y., Kim, D. & Zhang, G. (2017). Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides. Obesity (Silver Spring), 25(1), 132-140. https://doi.org/10.1002/oby.21692.
  • Wang, W., Yang, J., Nimiya, Y., Lee, K.S.S., Sanidad, K., Qi, W., Sukamtoh, E., Park, Y., Liu, Z. & Zhang, G.(2017). ω-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. J Nutr Biochem, 48, 29-35. https://doi.org/10.1016/j.jnutbio.2017.06.006.
  • Wang, W., Yang, H., Johnson, D., Gensler, C., Decker, E. & Zhang, G. (2017). Chemistry and biology of ω-3 PUFA peroxidation-derived compounds. Prostaglandins Other Lipid Mediat, 132, 84-91. https://doi.org/10.1016/j.prostaglandins.2016.12.004.
  • Vieira, S.A., Zhang, G. & Decker, E.A. (2017). Biological Implications of Lipid Oxidation Products. J Am Oil Chem Soc, 94(3), 339-351. https://doi.org/10.1007/s11746-017-2958-2.
  • Kharat, M., Du, Z., Zhang, G. & McClements, D.J. (2017). Physical and Chemical Stability of Curcumin in Aqueous Solutions and Emulsions: Impact of pH, Temperature, and Molecular Environment. J Agric Food Chem, 65(8), 1525-1532. https://doi.org/10.1021/acs.jafc.6b04815.
  • Guo, X., Li, J., Tang, R., Zhang, G., Zeng, H., Wood, R.J. & Liu, Z. (2017). High Fat Diet Alters Gut Microbiota and the Expression of Paneth Cell-Antimicrobial Peptides Preceding Changes of Circulating Inflammatory Cytokines. Mediators Inflamm, 2017, 9474896. https://doi.org/10.1155/2017/9474896. 

2016

  • Zou, L., Zheng, B., Zhang, R., Zhang, Z., Liu, W., Liu, C., Zhang, G., Xiao, H. & McClements, D.J. (2016). Influence of Lipid Phase Composition of Excipient Emulsions on Curcumin Solubility, Stability, and Bioaccessibility. Food Biophysics, 11(3), 213-225. https://doi.org/10.1007/s11483-016-9432-9.
  • Zhang, R., Zhang, Z., Zou, L., Xiao, H., Zhang, G., Decker, E.A. & McClements, D.J. (2016). Enhancement of carotenoid bioaccessibility from carrots using excipient emulsions: influence of particle size of digestible lipid droplets. Food Funct, 7(1), 93-103. https://doi.org/10.1039/c5fo01172h.
  • Wang, W., Yang, J., Yang, H., Sanidad, K.Z., Hammock, B.D., Kim, D. & Zhang, G. (2016). Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice. Prostaglandins Other Lipid Mediat, 127, 9-13. https://doi.org/10.1016/j.prostaglandins.2016.11.003.
  • Wang, W., Du, Z., Nimiya, Y., Sukamtoh, E., Kim, D. & Zhang, G. (2016). Allicin inhibits lymphangiogenesis through suppressing activation of vascular endothelial growth factor (VEGF) receptor. J Nutr Biochem, 29, 83-89. https://doi.org/10.1016/j.jnutbio.2015.11.004.
  • Sanidad, K.Z., Zhu, J., Wang, W., Du, Z. & Zhang, G. (2016). Effects of Stable Degradation Products of Curcumin on Cancer Cell Proliferation and Inflammation. J Agric Food Chem, 64(48), 9189-9195. https://doi.org/10.1021/acs.jafc.6b04343.
  • Sanidad, K.Z., Sukamtoh, E., Wang, W., Du, Z., Florio, E., He, L., Xiao, H., Decker, E.A. & Zhang, G. (2016). Oxidative Conversion Mediates Antiproliferative Effects of tert-Butylhydroquinone: Structure and Activity Relationship Study. J Agric Food Chem, 64(19), 3743-3748. https://doi.org/10.1021/acs.jafc.6b00711. 

  • Nimiya, Y., Wang, W., Du, Z., Sukamtoh, E., Zhu, J., Decker, E. & Zhang, G. (2016). Redox modulation of curcumin stability: Redox active antioxidants increase chemical stability of curcumin. Mol Nutr Food Res, 60(3), 487-494. https://doi.org/10.1002/mnfr.201500681. 

    Featured as journal front cover: https://doi.org/10.1002/mnfr.201670031

2015

  • Zhang, R., Zhang, Z., Zou, L., Xiao, H., Zhang, G., Decker, E.A. & McClements, D.J. (2015). Impact of Lipid Content on the Ability of Excipient Emulsions to Increase Carotenoid Bioaccessibility from Natural Sources (Raw and Cooked Carrots). Food Biophysics, 11(1), 71-80. https://doi.org/10.1007/s11483-015-9418-z.
  • Zhang, R., Zhang, Z., Zou, L., Xiao, H., Zhang, G., Decker, E.A. & McClements, D.J. (2015). Enhancing Nutraceutical Bioavailability from Raw and Cooked Vegetables Using Excipient Emulsions: Influence of Lipid Type on Carotenoid Bioaccessibility from Carrots. J Agric Food Chem, 63(48), 10508-10517.https://doi.org/10.1021/acs.jafc.5b04691.
  • Wu, X., Song, M., Wang, M., Zheng, J., Gao, Z., Xu, F., Zhang, G. & Xiao, H. (2015). Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis. Mol Nutr Food Res, 59(12), 2383-2394. https://doi.org/10.1002/mnfr.201500378.
  • Wang, W., Sukamtoh, E., Xiao, H. & Zhang, G. (2015). Curcumin inhibits lymphangiogenesis in vitro and in vivo. Mol Nutr Food Res, 59(12), 2345-2354. https://doi.org/10.1002/mnfr.201500399. 

2014

  • Zhang, G., Panigrahy, D., Hwang, S.H., Yang, J., Mahakian, L.M., Wettersten, H.I., Liu, J.Y., Wang, Y., Ingham, E.S., Tam, S., Kieran, M.W., Weiss, R.H., Ferrara, K.W. & Hammock, B.D. (2014). Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A, 111(30), 11127-11132. https://doi.org/10.1073/pnas.1410432111. 

    Media coverage by UC-Davis and Science Daily

  • Zhang, G., Kodani, S. & Hammock, B.D. (2014). Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog Lipid Res, 53, 108-123. https://doi.org/10.1016/j.plipres.2013.11.003.
  • Wang, W., Zhu, J., Lyu, F., Panigrahy, D., Ferrara, K.W., Hammock, B. & Zhang, G. (2014). ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins Other Lipid Mediat, 113-115, 13-20. https://doi.org/10.1016/j.prostaglandins.2014.07.002. 

Before 2014

  • Zhang, G. & Parkin, K.L. (2013). S-alk(en)ylmercaptocysteine: chemical synthesis, biological activities, and redox-related mechanism. J Agric Food Chem, 61(8), 1896-1903. https://doi.org/10.1021/jf305486q.
  • Zhang, G. & Parkin, K.L. (2013). A tissue homogenate method to prepare gram-scale Allium thiosulfinates and their disulfide conjugates with cysteine and glutathione. J Agric Food Chem, 61(12), 3030-3038. https://doi.org/10.1021/jf4003818. 

  • Zhang, G., Panigrahy, D., Mahakian, L.M., Yang, J., Liu, J.Y., Stephen Lee, K.S., Wettersten, H.I., Ulu, A., Hu, X., Tam, S., Hwang, S.H., Ingham, E.S., Kieran, M.W., Weiss, R.H., Ferrara, K.W. & Hammock, B.D. (2013). Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A, 110(16), 6530-6535. https://doi.org/10.1073/pnas.1304321110. 

    Media coverage by UC-Davis Department and Medical School, National Institute of Environmental Health Sciences and Science Daily

  • Zhang, G., Nitteranon, V., Guo, S., Qiu, P., Wu, X., Li, F., Xiao, H., Hu, Q. & Parkin, K.L. (2013). Organoselenium compounds modulate extracellular redox by induction of extracellular cysteine and cell surface thioredoxin reductase. Chem Res Toxicol, 26(3), 456-464. https://doi.org/10.1021/tx300515j.
  • Zhang, G., Nitteranon, V., Chan, L.Y. & Parkin, K.L. (2013). Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger. Food Chem, 140(1-2), 1-8. https://doi.org/10.1016/j.foodchem.2013.02.073.
  • Van Bogaert, I., Zhang, G., Yang, J., Liu, J.Y., Ye, Y., Soetaert, W. & Hammock, B.D. (2013). Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. J Lipid Res, 54(11), 3215-3219. https://doi.org/10.1194/jlr.D042226.
  • Hwang, S.H., Wecksler, A.T., Zhang, G., Morisseau, C., Nguyen, L.V., Fu, S.H. & Hammock, B.D. (2013). Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors. Bioorg Med Chem Lett, 23(13), 3732-3737. https://doi.org/10.1016/j.bmcl.2013.05.011.
  • Lu, A., Ma, Z., Zhuo, J., Sun, G. & Zhang, G. (2012). Layer‐by‐layer structured gelatin nanofiber membranes with photoinduced antibacterial functions. J Appl Polym Sci, 128(2), 970-975. https://doi.org/10.1002/app.38131.
  • Li, F., Nitteranon, V., Tang, X., Liang, J., Zhang, G., Parkin, K.L. & Hu, Q. (2012). In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food Chem, 135(2), 332-337. https://doi.org/10.1016/j.foodchem.2012.04.145.
  • Nitteranon, V., Zhang, G., Darien, B.J. & Parkin, K. (2011). Isolation and synergism of in vitro anti-inflammatory and quinone reductase (QR) inducing agents from the fruits of Morinda citrifolia (noni). Food Res Int, 44(7), 2271-2277. https://doi.org/10.1016/j.foodres.2010.11.009.
  • Lu, A., Zhu, J., Zhang, G. & Sun, G. (2011). Gelatin nanofibers fabricated by extruding immiscible polymer solution blend and their application in tissue engineering. J Mater Chem, 21(46), 18674-18680. https://doi.org/10.1039/c1jm13059e.
  • Zhang, G., Li, B., Lee, C.H. & Parkin, K.L. (2010). Cysteine and glutathione mixed-disulfide conjugates of thiosulfinates: chemical synthesis and biological activities. J Agric Food Chem, 58(3), 1564-1571. https://doi.org/10.1021/jf9029354.
  • Imm, J., Zhang, G., Chan, L.-Y., Nitteranon, V. & Parkin, K.L. (2010). [6]-Dehydroshogaol, a minor component in ginger rhizome, exhibits quinone reductase inducing and anti-inflammatory activities that rival those of curcumin. Food Res Int, 43(8), 2208-2213. https://doi.org/10.1016/j.foodres.2010.07.028.